Hey everyone, this is a tutorial on the immune system which covers both the innate and acquired immune system.

Innate Immune System
1. PRRs located on neutrophils, mast, macrophage, dendridic recognize PAMP
2. Release of cytokines especially IL-1 and TNFa which act on post-cappiliary venule endothelial cells
3. This leads to adhesion molecules, vasodilation and exudate
4. Adhesion molecules: “chemotaxins” IL-8, C5a, LTB4, cause rolling of leukocytes on endothelial cells, adhesion, and migration to pathogen
5. Tissue damage releases eicosanoids: prostaglandins PGI2, PGE2 (vasodilation) and leukotriene LTB4
6. Opsonins created from complement cascade: C3b
7. Cytokines stimulate synthesis of vasodilator nitric oxide, increasing vascular permeability.

For the acquired immune system, I go over how antigen presenting cells work in combination with T lymphocytes helper and T lymphocyte cytotoxic cells.

Video by medschoolblog