Video

The Necessity of the Immune System

(March 30, 2010) David Lewis provides an overview of the human immune system, answering questions on how innate and adaptive immunity are integrated to optimize the immune response.

During the final quarter of the Stanford Mini Med School, some of the most timely and important topics in contemporary medicine and the biosciences are addressed.

Stanford Mini Med School is a series arranged and directed by Stanford’s School of Medicine, and presented by the Stanford Continuing Studies program.

Stanford University:
http://www.stanford.edu

Stanford Medical School:
http://med.stanford.edu/

Stanford Continuing Studies:
http://continuingstudies.stanford.edu/

Stanford University Channel on YouTube:
http://www.youtube.com/stanford/

Video

Cell Communication and Immunology


Frontiers of Biomedical Engineering (BENG 100)

Professor Saltzman talks about cell communication, specifically ligand-receptor interactions that are important in maintaining homeostasis in the body. Different types of receptors and ligands, the nature of their interactions and ways to apply this into developing drugs are discussed (eg. Aldopa, Taximofen, beta-blockers). Next, Professor Saltzman talks about kinases, phosphatases, cyclic AMP and the mechanism of switching protein states. Three categories of cell communication signals are introduced: autocrine, paracrine, and endocrine. Finally, an example of cell communication using regulation/response to blood sugar level is presented.

00:00 – Chapter 1. Overview of Cell Communication
07:39 – Chapter 2. Mechanisms of Cell Communication
16:27 – Chapter 3. Agonists and Antagonists
21:31 – Chapter 4. Receptors
28:02 – Chapter 5. Protein Signal Transduction
34:54 – Chapter 6. Autocrines, Paracrines, Endocrines

Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses

This course was recorded in Spring 2008.

Video by YaleCourses

Video

The Immune System Overview & Tutorial

Hey everyone, this is a tutorial on the immune system which covers both the innate and acquired immune system.

Innate Immune System
1. PRRs located on neutrophils, mast, macrophage, dendridic recognize PAMP
2. Release of cytokines especially IL-1 and TNFa which act on post-cappiliary venule endothelial cells
3. This leads to adhesion molecules, vasodilation and exudate
4. Adhesion molecules: “chemotaxins” IL-8, C5a, LTB4, cause rolling of leukocytes on endothelial cells, adhesion, and migration to pathogen
5. Tissue damage releases eicosanoids: prostaglandins PGI2, PGE2 (vasodilation) and leukotriene LTB4
6. Opsonins created from complement cascade: C3b
7. Cytokines stimulate synthesis of vasodilator nitric oxide, increasing vascular permeability.

For the acquired immune system, I go over how antigen presenting cells work in combination with T lymphocytes helper and T lymphocyte cytotoxic cells.

Video by medschoolblog