Steve Kroft profiles famous microbiologist J. Craig Venter, whose scientists have already mapped the human genome and created what he calls “the first synthetic species.”
Reply
Drug company whistle-blower Cheryl Eckard tells Scott Pelley about her experience trying to fix problems at a pharmaceutical factory that made her a key figure in a federal lawsuit and a multimillionaire.
Dr. Nora Volkow, the head of the National Institute on Drug Abuse, has revolutionized how science and medicine view addiction: as a disease, not a character defect. Morley Safer reports.
Video
Basic Immunology
Basic Immunology: Nuts and Bolts of the Immune System
Video by UCtelevision
Lesley Stahl interviews the handful of individuals known to possess the skill of near endless memory, which scientists are only now beginning to study.
In Iraq, where many biblical scholars place the Garden of Eden, Scott Pelley finds a water world where the Marsh Arabs are making a comeback after Saddam nearly destroyed the cradle of civilization.
Frontiers of Biomedical Engineering (BENG 100)
Professor Saltzman talks about cell communication, specifically ligand-receptor interactions that are important in maintaining homeostasis in the body. Different types of receptors and ligands, the nature of their interactions and ways to apply this into developing drugs are discussed (eg. Aldopa, Taximofen, beta-blockers). Next, Professor Saltzman talks about kinases, phosphatases, cyclic AMP and the mechanism of switching protein states. Three categories of cell communication signals are introduced: autocrine, paracrine, and endocrine. Finally, an example of cell communication using regulation/response to blood sugar level is presented.
00:00 – Chapter 1. Overview of Cell Communication
07:39 – Chapter 2. Mechanisms of Cell Communication
16:27 – Chapter 3. Agonists and Antagonists
21:31 – Chapter 4. Receptors
28:02 – Chapter 5. Protein Signal Transduction
34:54 – Chapter 6. Autocrines, Paracrines, Endocrines
Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses
This course was recorded in Spring 2008.
Video by YaleCourses
Steve Kroft takes a look at Grover Norquist, the man many blame for holding up the deficit-reduction process because of the anti-tax pledges he has obtained from nearly all the Republican politicians in Washington.
Hey everyone, this is a tutorial on the immune system which covers both the innate and acquired immune system.
Innate Immune System
1. PRRs located on neutrophils, mast, macrophage, dendridic recognize PAMP
2. Release of cytokines especially IL-1 and TNFa which act on post-cappiliary venule endothelial cells
3. This leads to adhesion molecules, vasodilation and exudate
4. Adhesion molecules: “chemotaxins” IL-8, C5a, LTB4, cause rolling of leukocytes on endothelial cells, adhesion, and migration to pathogen
5. Tissue damage releases eicosanoids: prostaglandins PGI2, PGE2 (vasodilation) and leukotriene LTB4
6. Opsonins created from complement cascade: C3b
7. Cytokines stimulate synthesis of vasodilator nitric oxide, increasing vascular permeability.
For the acquired immune system, I go over how antigen presenting cells work in combination with T lymphocytes helper and T lymphocyte cytotoxic cells.
Video by medschoolblog